Noul’s Hydrogel Stamping is the key potential technology needed for accurate cancer diagnosis, the study confirmed

  • The method shows very efficient and simple in immuno-staining
  • Research paper by Biotech Start up Noul, Harvard Medical Schooland Massachusetts General Hospital Published in Applied Materials and Interfaces of the American Chemical Society.

FIRE, South Korea, July 27, 2022 /PRNewswire/ — A new study by Noul Co., Ltd., (376930.KR), a biotechnology startup listed on KOSDAQ, Harvard Medical School and the Massachusetts Clinical Hospital was published in the American Chemical Society Applied Materials and Interfaces, a well-known academic journal.

Hydrogel stamping is part of NGSI (Next Generation Staining & Immunostaining) technology, which is Noul’s proprietary technology that uses solid-based staining instead of the conventional liquid-based staining that laboratories around the world have used for more than a century. This drastically reduces the amount of sample required by up to 1/100 and eliminates the need for cleaning or drying, thus generating zero wastewater in the process.

According to the paper, Hydrogel Imprinting for Rapid, Multiplexed, Point-of-Care Immunostaining of Cells and Tissues, Noul’s hydrogel imprinting enabled quality immunostaining in one-sixth the time for cells using one-eighth the antibody consumption compared to the conventional solution-based method. .

Hydrogel Stamping identified up to nine biomarkers that diagnose breast cancer even though the amount of antibodies was reduced. This study confirmed the potential of Hydrogel-based immunostaining as an essential technology needed for accurate cancer diagnosis.

Researchers performed clinical evaluation of immunohistochemical staining (IHC) and biomarkers (HER2, ER, PR) using tissue samples from 12 breast cancer patients. The study concluded that the developed hydrogel imprinting is a very efficient and simple immunostaining method for staining cells and tissue samples. In addition, when multiple fluorescence is applied to a hydrogel used for staining, multiple analysis is possible, enabling accurate diagnosis.

Meanwhile, Noul is conducting R&D on next-generation diagnostic tests and precision medicine to expand the application of Noul’s original technologies and provide new technologies. In 2021, Noul published the paper in the same journal, presenting NGSI as a simple, reproducible and reasonable method that does not require a special staining reagent for staining blood cells.

David LimNoul’s CEO said: “Based on deep technology such as bio, SW/AI and platforms, Noul has developed and introduced an irreplaceable decentralized diagnostic platform to the market. Through proactive and continuous R&D, we will ensure the reliability of our products and we will build various foundations to confirm our technological capabilities in next-generation diagnostic tests and precision medicine fields, which are included in Noul’s future portfolio.”

About Noul

Noul, a biotech startup that develops and manufactures next-generation diagnostic platforms, was founded in December 2015 based on the mission of ‘exploring global challenges that threaten human health and life, discover new potential solutions and realize those opportunities’. At Noul, experts from various fields including bio, AI, S/W, mechanics and manufacturing are brought together to solve important human health problems.

Noul’s flagship product, the miLab™ Diagnostic Platform, is a decentralized diagnostic platform that provides on-site diagnosis. It is a solution that differentiates diagnostic ease while maintaining the accuracy of microscopic diagnostic procedures which is known as the gold standard in blood diagnostics. From sample preparation to image analysis and AI, miLab™ performs microscopic diagnosis procedures on a fully automated benchtop platform and provides an accurate analysis in 15 minutes using only 5 µl of blood.

Noul has strived to grow into a company based on the philosophy of sustainability since its founding. Taking sustainability as its central corporate management philosophy, Noul focuses on internalizing sustainability values ​​in business practices, technology and product developments, and organizational operations. Noul’s sustainability is to comply with ethical and legal standards as a corporate citizen and to balance economic, social and environmental values ​​in responsible relationships with stakeholders.



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